Taking whole food multivitamins has been shown to offer numerous health benefits. These supplements provide more of the nutrients your body needs, such as calcium, dietary fiber, and potassium. Having a more comprehensive daily nutritional profile can enhance immune system response, energy levels, focus, and even performance in physical activities.

Long-term use of whole food multivitamins has been associated with other significant benefits. Studies have found connections between taking whole food multivitamins and improved memory, better eye health, and a reduced risk of heart disease.

Multivitamin supplements fall into two main categories: whole food and synthetic. Both contain nutrients that can supplement your diet. The distinction lies in the fact that the nutrients in synthetic supplements are artificially produced. This can make it more challenging for your body to recognize and process these nutrients because they differ from what you regularly consume.

Whole food multivitamins are nutritional supplements that provide a concentrated version of the nutrients found in fruits, vegetables, and eggs. Due to their natural ingredients, your body can more easily absorb the contents of these supplements and enjoy their benefits.

Whole food multivitamins are an excellent choice, offering natural nutrition similar to what you get from food. By using whole food supplements, you can experience a range of health benefits.

While people used to obtain the necessary vitamins and minerals from their diets, the modern Western diet often lacks essential fruits, vegetables, and lean proteins, leading to potential nutritional deficiencies. Processed foods, simple carbohydrates, and unhealthy fats are prevalent in the Western diet, resulting in many individuals not receiving adequate amounts of vitamins and minerals from their food. This can lead to nutritional deficiencies despite consuming enough calories. Common deficiencies in the United States include vitamin D, vitamin B12, calcium, iron, iodine, vitamin A, and magnesium, affecting a significant portion of the population. To address these deficiencies and fill nutritional gaps, some people turn to multivitamins. In addition to addressing potential deficiencies, multivitamins can also offer the following benefits:

- Reduced risk of certain types of cancers caused by nutritional deficiencies
- Lower risk of heart attacks and death from heart disease
- Decreased risk of age-related macular degeneration in older adults
- Improved memory in older adults

Taking whole food multivitamins has been shown to offer numerous health benefits. These supplements provide more of the nutrients your body needs, such as calcium, dietary fiber, and potassium. Having a more comprehensive daily nutritional profile can enhance immune system response, energy levels, focus, and even performance in physical activities.

Long-term use of whole food multivitamins has been associated with other significant benefits. Studies have found connections between taking whole food multivitamins and improved memory, better eye health, and a reduced risk of heart disease.

Multivitamin supplements fall into two main categories: whole food and synthetic. Both contain nutrients that can supplement your diet. The distinction lies in the fact that the nutrients in synthetic supplements are artificially produced. This can make it more challenging for your body to recognize and process these nutrients because they differ from what you regularly consume.

Whole food multivitamins are nutritional supplements that provide a concentrated version of the nutrients found in fruits, vegetables, and eggs. Due to their natural ingredients, your body can more easily absorb the contents of these supplements and enjoy their benefits.

Whole food multivitamins are an excellent choice, offering natural nutrition similar to what you get from food. By using whole food supplements, you can experience a range of health benefits.

While people used to obtain the necessary vitamins and minerals from their diets, the modern Western diet often lacks essential fruits, vegetables, and lean proteins, leading to potential nutritional deficiencies. Processed foods, simple carbohydrates, and unhealthy fats are prevalent in the Western diet, resulting in many individuals not receiving adequate amounts of vitamins and minerals from their food. This can lead to nutritional deficiencies despite consuming enough calories. Common deficiencies in the United States include vitamin D, vitamin B12, calcium, iron, iodine, vitamin A, and magnesium, affecting a significant portion of the population. To address these deficiencies and fill nutritional gaps, some people turn to multivitamins. In addition to addressing potential deficiencies, multivitamins can also offer the following benefits:

- Reduced risk of certain types of cancers caused by nutritional deficiencies
- Lower risk of heart attacks and death from heart disease
- Decreased risk of age-related macular degeneration in older adults
- Improved memory in older adults

The organic zinc drops provide numerous health benefits, such as supporting immune function, helps to maintain skin health, and much more. Additionally, the Organic Zinc drops help support male sexual health and support the immune system to you remain healthy.

Category	Recommended Dietary Allowance (RDA) of Zinc
CHILDREN
7 months to 3 years	3 mg/day
4-8 years	5 mg/day
9-13 years	8 mg/day
FEMALES
14-18 years	9 mg/day
19 years and up	8 mg/day
Pregnant	14-18 years: 12 mg/day 19 years and over: 11 mg/day
Breastfeeding	14-18 years: 13 mg/day 19 years and over: 12 mg/day
MALES
14 years and up	11 mg/day

• Treats zinc deficiency. Zinc supplements are often used to help treat and prevent zinc deficiency. ...
• May improve immune function. ...
• May promote blood sugar management. ...
• Helps fight acne. ...
• May improve heart health. ...
• Slows macular degeneration.

What type of zinc should I take for acne?

A dose of between 80 to 140 mg elemental zinc is recommended for the treatment of acne. The RDI (recommended daily intake) ranges from 10 to 15 mg. Some studies have shown that zinc sulphate is the most effective type of zinc supplement for the management of acne. Higher doses can cause side effects such as abdominal upset. 

GSH plays an important role in maintenance of numerous immune functions including lymphocyte proliferation and NK cell activity ^37–39. We found that liposomal GSH administration resulted in increases in both of these activities; lymphocyte proliferation was enhanced up to 60% and as early as 1 wk and NK cell cytotoxicity was increased up to 400% and as early as 2 wk. Further, the time course of these effects on immune function coincided with the observed increases in PBMC GSH content

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function.
Raghu Sinha, Indu Sinha, Ana Calcagnotto, Neil Trushin, Jeremy S. Haley, Todd D. Schell, and John P. Richie, Jr.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389332/

• Continuous and consistent supplementation will result into gradual skin lightening.
• Its dosage and results depend upon body weight as well as color of skin for eg. results visible on Light-medium brown skin: 1-3 months, Dark brown skin: 3-6 months, Very dark skin: 6-12 months & Black skin: 18 months minimum and above.
• A Glutathione efficacy in skin lightening works only if it is taken with Vitamin C at least equal or twice its dosage.

Glutathione supplement for skin lightening and anti-ageing

Liposomal GSH appeared to be effective at two doses (500 and 1000 mg/d) and effects were seen as early as 1 week.
In addition, liposomal GSH had positive effects on several GSH-related parameters including decreases in biomarkers of oxidative stress and enhancements in immune functions. Finally, liposomal GSH was highly tolerated and its administration was not associated with any signs of adverse effects.

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function.
Raghu Sinha, Indu Sinha, Ana Calcagnotto, Neil Trushin, Jeremy S. Haley, Todd D. Schell, and John P. Richie, Jr.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389332/

• Glutathione depletion due to aging and toxins can be countered by supplementation. Incorporating glutathione into your daily routine can protect the skin, resulting in a brighter, more youthful complexion.
• Glutathione helps boost the immune system, supports liver cleansing, promotes cardiovascular health, and enhances vital brain functions such as mental focus, clarity, and memory.
• Liposomal glutathione is a great way to improve cellular function, respiration, and oxidation.
• Liposomal glutathione is also a core component to protecting your immune system and aids the cells that are its first line of defense against infections and viruses.

B vitamins play a vital role in maintaining good health and well-being. As the building blocks of a healthy body, B vitamins have a direct impact on your energy levels, brain function, and cell metabolism.

Vitamin B complex may help prevent infections and help support or promote:

• cell health
• growth of red blood cells
• energy levels
• eyesight
• brain function
• digestion
• appetite
• proper nerve function
• hormones and cholesterol production
• cardiovascular health
• muscle tone

People with vitamin B deficiency may experience:

• fatigue, weakness or a general lack of energy
• numbness or tingling in their hands and feet
• weakened muscles and slow reflexes
• ‘shakiness’ when walking or difficulty keeping balance

More severe symptoms include confusion, a loss of memory, depression and dementia.

• thiamin (B1)
• riboflavin (B2)
• niacin (B3)
• pantothenic acid (B5)
• pyridoxine (B6)
• biotin (B7)
• folate or 'folic acid' when included in supplements (B9)
• cyanocobalamin (B12).

Evidence from human research clearly shows both that a significant proportion of the populations of developed countries suffer from deficiencies or insufficiencies in one or more of this group of vitamins, and that, in the absence of an optimal diet, administration of the entire B-vitamin group, rather than a small sub-set, at doses greatly in excess of the current governmental recommendations, would be a rational approach for preserving brain health.

B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review,  David O. Kennedy

Although dietary B vitamins are generally absorbed through the small intestine, bacterial B vitamins are produced and absorbed mainly through the colon (1), indicating that dietary and gut microbiota-derived B vitamins are possibly handled differently by the human body

1. Said HM. Intestinal absorption of water-soluble vitamins in health and disease. Biochem J. (2011) 437:357–72. 10.1042/BJ20110326

Vitamins are micronutrients that have physiological effects on various biological responses, including host immunity. Therefore, vitamin deficiency leads to increased risk of developing infectious, allergic, and inflammatory diseases. Since B vitamins are synthesized by plants, yeasts, and bacteria, but not by mammals, mammals must acquire B vitamins from dietary or microbial sources, such as the intestinal microbiota. Similarly, some intestinal bacteria are unable to synthesize B vitamins and must acquire them from the host diet or from other intestinal bacteria for their growth and survival. This suggests that the composition and function of the intestinal microbiota may affect host B vitamin usage and, by extension, host immunity. Here, we review the immunological functions of B vitamins and their metabolism by intestinal bacteria with respect to the control of host immunity.

1. Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478888/#B11

There are 13 vitamins that our body needs, 8 of which make up the B-group (or B-complex) vitamins.
Without B-group vitamins the body lacks energy. This is because the B-group vitamins are needed to help the body to use the energy-yielding nutrients (such as carbohydrates, fat and protein) for fuel. Other B-group vitamins are needed to help cells to multiply by making new DNA.

The B-vitamins comprise a group of eight water soluble vitamins that perform essential, closely inter-related roles in cellular functioning, acting as co-enzymes in a vast array of catabolic and anabolic enzymatic reactions. Their collective effects are particularly prevalent to numerous aspects of brain function, including energy production, DNA/RNA synthesis/repair, genomic and non-genomic methylation, and the synthesis of numerous neurochemicals and signaling molecules. However, human epidemiological and controlled trial investigations, and the resultant scientific commentary, have focused almost exclusively on the small sub-set of vitamins (B₉/B₁₂/B₆) that are the most prominent (but not the exclusive) B-vitamins involved in homocysteine metabolism. Scant regard has been paid to the other B vitamins. This review describes the closely inter-related functions of the eight B-vitamins and marshals evidence suggesting that adequate levels of all members of this group of micronutrients are essential for optimal physiological and neurological functioning. Furthermore, evidence from human research clearly shows both that a significant proportion of the populations of developed countries suffer from deficiencies or insufficiencies in one or more of this group of vitamins, and that, in the absence of an optimal diet, administration of the entire B-vitamin group, rather than a small sub-set, at doses greatly in excess of the current governmental recommendations, would be a rational approach for preserving brain health.

B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/

A study in 60 adults with depression showed that treatment with a vitamin B complex for 60 days led to significant improvements in depression and anxiety symptoms, compared with a placebo. B vitamins may also enhance treatment response when given in combination with antidepressant medication.

The Effect of Methylated Vitamin B Complex on Depressive and Anxiety Symptoms and Quality of Life in Adults with Depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658370/

A diet rich in quercetin has various health-promoting benefits. It acts as an agent to lower coagulation, hyperglycemia, inflammation, and hypertension. Various clinical studies show that supplementation of quercetin is used to prevent and treat various chronic diseases such as cardiovascular disorders.

Health Benefits of Quercetin in Age-Related Diseases, Deepika and Pawan Kumar Maurya.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032170/

.

Quercetin functions on an antioxidant level to reduce damage and irritation caused by free radicals while suppressing your histamine response – the body's reaction to allergens. Bromelain functions on an enzymatic and protein level by limiting the action of metabolites and neutrophils in the inflammatory process.
The combination of quercetin with bromelain has anti-inflammatory actions that counteract the physiological stressors on athletes' bodies. Research indicates that quercetin is also a potent antioxidant that scavenges free radicals to reduce tissue and DNA damage, especially for endurance athletes.

One small study examined quercetin's possible effects on inflammation, disease severity, and symptoms in women with rheumatoid arthritis. The trial included 50 individuals who were sorted into a quercetin supplementation group or a placebo group for eight weeks. Quercetin users took 500 milligrams (mg) daily.

After eight weeks, those who received quercetin reported significantly reduced early morning stiffness, morning pain, and after-activity pain, according to the results. Quercetin users also had reduced markers of inflammation compared to those in the placebo group.

The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: A double-blind, randomized controlled trial. 
Javadi F, Ahmadzadeh A, Eghtesadi S, et al. 
J Am Coll Nutr. 2017;36(1):9-15. doi:10.1080/07315724.2016.1140093

Like most vitamin supplements that can be taken daily, it's generally accepted as safe to take quercetin every day. As with many supplements, taking quercetin with food is recommended. So ideally the best time to take it is with your breakfast or evening meal.

This anxiolytic effect of quercwtin has been shown to be due to its anti-inflammatory effects and appropriate regulation of BDNF and iNOS expression. Thus, QUER provides the potential as a therapeutic agent to inhibit anxiety-like symptoms in neuropsychiatric diseases, such as anxiety.

Protective Effects of Quercetin on Anxiety-Like Symptoms and Neuroinflammation Induced by Lipopolysaccharide in Rats.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204389

The flavonoid Quercetin is not the same as CoQ10. As mentioned above, quercetin is a dietary flavonoid found in numerous fruits and vegetables, particularly onions, kale, and chili peppers. Coenzyme Q10 (CoQ10) is a biologically active quinone that plays a vital role in the mitochondrial electron transport chain.

Flavonoid content of U.S. fruits, vegetables, and nuts.
https://pubmed.ncbi.nlm.nih.gov/17177529/

Quercetin and bromelain have several health benefits for women, including:

• Quercetin has antioxidant and anti-inflammatory effects that might help reduce swelling, kill cancer cells, control blood sugar, and help prevent heart disease.
• Bromelain is a highly effective anti-inflammatory that can help to relieve joint and connective tissue pain, and reduce C-reactive protein, the inflammation marker.
• Bromelain magnifies the efficacy of quercetin.
• Quercetin has anti-oxidative, anti-inflammatory, anti-bacterial, immunomodulatory, and cardio-protective actions.
• Bromelain reduces inflammation in women suffering from endometriosis and even shrinks the size and number of cysts.

Vitamin C can promote good health in several ways by:

• Supporting the immune system
• Reducing tiredness and fatigue
• Helping the nervous system function normally
• Helping the body mitigate and fight off the symptoms of viral infections such as the common cold and ‘flu
• Stimulating the production of infection-fighting white blood cells
• contains powerful antioxidant properties and helps protect against free radical damagehelps healthy brain function and cognition
• cardiovascular and heart health, adrenal, blood circulation & mood
• helps bone density, helps decrease muscle soreness, collagen booster, skin
• helps increase absorption of calcium & iron.

Virtually all our cells depend on vitamin C to some extent: it really is a vital nutrient for optimum health.  And if we’re stressed or unwell, this can deplete our stores even further, so we really have to be vigilant and take vitamin C each day.

Liposomal Vitamin C is a type of Vitamin C that is better absorbed by the body than regular Vitamin C.
Liposomes are tiny, nano-sized bubbles that mimic the body's own cell membranes.
By protecting and helping Vitamin C travel through the body, liposomes aid and speed absorption.

There are two main reasons for this:

1) our digestive system breaks it down and destroys it in our gut or intestine

2) it’s a water-soluble vitamin so even if it gets past our gut and reaches our cells, it can’t ‘get in’ because it’s incompatible with the fat-based membrane of our cells

For Vitamin C to reach our body’s cells, it must be protected from the digestive system’s juices and ‘presented’ in a fat-friendly form that can pass through our cell membranes.

This can be done by encasing the vitamin C in a protective bubble of fat-based liposomes which will safely pass through the digestive system undamaged. Then, when they reach the body’s cells, they successfully move through the fat-based cell membrane to arrive inside the cells ready to work.

The results of the clinical studies of liposomal vitamin C by oral delivery to be 1.77 times more bioavailable than non-liposomal vitamin C. The liposomal vitamin C demonstrated higher values of C_max, AUC_0-t and AUC_0-∞ related to non-liposomal vitamin C due to liposomal encapsulation.

Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability
https://pubmed.ncbi.nlm.nih.gov/32901526/

Typically, liposomal vitamin C is thought to be 5-10 times more bioavailable (taken up by the body’s cells) compared to traditional vitamin C supplements.  This means that you can achieve optimal results with a smaller dose.

You can take it at any time of day with or without food.  It’s best to drink a glass of water as you take the Liposomal vitamin C.

A recommended dose of 1-1.5g/1000-1500mg of Liposomal vitamin C per day

 

In general, there are very minimal side effects to liposomal vitamin C as it is difficult to overdose on Vitamin C considering the upper limit is 2,000 mg per day. This is almost impossible to get through food alone and is mainly worth taking into consideration if you are supplementing.

While it's always advisable to seek personalized advice from a healthcare professional, here are some considerations to keep in mind:

• Nutritional Support: As women age, their nutritional requirements may change due to factors such as hormonal changes, reduced absorption of certain nutrients, and lifestyle factors. A multivitamin supplement can help address potential nutrient deficiencies and provide essential vitamins and minerals necessary for overall health and well-being.
• Bone Health: Women over forty are at a higher risk of osteoporosis and bone fractures. Some multivitamin supplements may contain calcium, vitamin D, and other nutrients that support bone health and reduce the risk of fractures. However, additional calcium and vitamin D supplementation may be necessary based on individual needs and bone health status.
• Heart Health: Cardiovascular disease becomes a significant concern for women as they age. Certain multivitamin formulations may include nutrients like vitamin B, vitamin E, and omega-3 fatty acids, which have been linked to heart health benefits. However, the evidence for the effectiveness of multivitamins in preventing heart disease is mixed, and lifestyle factors such as a balanced diet and regular exercise remain crucial for heart health.
• Energy and Vitality: Women in their forties and beyond often experience changes in energy levels and vitality. Multivitamin supplements can provide a range of B vitamins that support energy metabolism and overall vitality. However, it's important to remember that a multivitamin should not replace a healthy diet and lifestyle.
• Individual Variations: It's important to recognize that the nutritional needs of individuals vary, and not all women will benefit equally from multivitamin supplements. Factors such as diet, overall health, existing nutrient deficiencies, and specific health conditions should be taken into account. Consulting with a healthcare professional can help determine whether a multivitamin supplement is suitable and beneficial for individual needs.

In summary, multivitamin supplements can potentially provide nutritional support for women over forty by addressing nutrient gaps and supporting specific health concerns such as bone health and energy levels. However, individual needs and circumstances vary, and it's important to seek guidance from a healthcare professional to determine the best approach to meeting specific nutritional requirements.

Consider the following supplements:

Folic Acid (Vitamin B9) - Research suggests that it may help prevent Alzheimer's disease, depression, and heart disease. It is recommended for women who are pregnant or planning to get pregnant to prevent birth defects.

Calcium - It is taken to strengthen bones, especially for those who consume little or no calcium-rich foods.

Iron - Anemia, or low blood levels of iron, is more common with age. It is recommended for people with diagnosed iron-deficiency anemia.

Vitamin E - Some believe it can help prevent cancer, dementia, and heart disease.

Additionally, consider the following supplements:

Vitamin D - Consider if you've been diagnosed with osteoporosis, get little sunlight, or rarely consume D-rich foods.

AREDS2 (a blend of vitamins C and E, copper, lutein, zeaxanthin, and zinc) - Consider if you have age-related macular degeneration, a leading cause of vision loss.

Vitamin B12 - Consider if you're a strict vegan, or if you regularly take certain kinds of heartburn drugs or metformin, a diabetes medication.

Omega 3 fish oil, Vitamin D, and Magnesium are three essential vitamins that can improve overall health and well-being. Omega 3 fish oil can improve brain function and reduce inflammation, Vitamin D can support bone health and boost immune function, and magnesium can support muscle and nerve function and reduce stress and anxiety. While these vitamins can be found in certain foods, taking a supplement can ensure that you are getting enough to meet your individual needs. Remember, it is important to talk to your doctor before starting any new supplement regimen.

Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017;45(5):1105-1115. Holick MF.
The vitamin D deficiency pandemic: a forgotten hormone important for health. Public Health Rev. 2010;32(1):267-283. Volpe SL.
Magnesium in disease prevention and overall health. Adv Nutr. 2013;4(3):378S-383S. Chinni V, Uppaluri KR.
Vitamin D Deficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. Grosso G, Galvano F, Marventano S, et al.
Omega-3 fatty acids and depression: scientific evidence and biological mechanisms. Oxid Med Cell Longev. 2014.

Promotes Healthy Aging: As we grow older, our bodies require more nutrients, but it becomes more challenging for the body to absorb them. Additionally, medications can deplete our nutrient levels. Taking a multivitamin can help counteract these deficiencies.
Supports Heart Health: Research indicates that a high-quality multivitamin may lower the risk of cardiovascular disease. Vitamins B1, B2, B6, K1, Niacin (B3), CoQ10, and magnesium all contribute to cardiovascular health.
Reduces Cancer Risk: Studies have linked vitamin use to a decreased risk of certain cancers. In fact, a study of 14,000 men aged 50 and older found that daily multivitamin supplementation significantly reduced the risk of total cancer.
Boosts Immunity: Vitamin C is a potent antioxidant known for strengthening the immune system, while vitamins D and E also support immunity and can help alleviate allergy symptoms.
Supports Eye Health: Vitamins A, C, E, Niacin (B3), and selenium promote eye health, and lutein and zeaxanthin protect the eyes from harmful light waves. Research has shown that multivitamins containing these vitamins and nutrients can reduce the risk of macular degeneration.
Water-Soluble Vitamins: Unlike fat-soluble vitamins, which are stored in the body, water-soluble vitamins (B and C) are not stored and are excreted from the body. Therefore, it is important to consume these essential vitamins daily.
Promotes Healthy Hair and Skin: Recent studies suggest that vitamins B3 (Niacin), biotin, and Vitamin C contribute to fuller hair, while vitamins A, C, E, and CoQ10 support healthy skin.
Enhances Well-Being: Multivitamins, particularly those containing Vitamin B, are associated with increased energy levels, improved well-being, and reduced stress and anxiety, making it worthwhile to maintain a multivitamin routine.

Avoid using magnolia during pregnancy.  

The active ingredients in the extracts have been identified as the bi-phenolic isomers magnolol and honokiol. These compounds were shown to enhance the activity of GABA_A receptors, consistent with their biological effects.

Extracts from the bark of magnolia have been found to provide protective benefits against numerous neurological problems.

These cover not only brain diseases such as Alzheimer's disease, but also conditions such asanxiety, mood imbalances, and depression.

In a research involving 40 women aged between 20 and 50, it was discovered that taking 250 mg of a magnolia and phellodendron bark extract three times daily resulted in a substantial reduction in temporary and short-term anxiety compared to a placebo.

Another research of the same magnolia and phellodendron bark extract involving 56 adults found that a daily intake of 500 mg of the extract led to significantly reduced cortisol levels and improved mood.

Cortisol is your body's primary stress hormone. A decrease in cortisol indicates a reduction in overall stress.

However, it's worth noting that the supplement used in these studies included compounds other than just magnolia bark. This suggests that the observed effects cannot be solely attributed to the tree bark.

Lastly, a rodent study showed that a combination of honokiol and magnolol produced antidepressant-like effects, which included an increase in brain serotonin levels and a decrease in corticosterone levels in the blood.

Both corticosterone and serotonin play essential roles in regulating anxiety, mood, and depression.

Used in ancient Asian medicine, the extracts of the magnolia tree’s bark have been touted for their curative and calming effects for centuries. They are now being researched in western culture as well. DHH-B is approximately 2,000% stronger than the often-mentioned extract, honokiol, for those familiar with magnolia bark extract.

https://pubmed.ncbi.nlm.nih.gov/33950239/

According to studies, DHH-B also activates cannabinoid receptors throughout the body. These receptors have a hand in immune systems, pain relief, and disease prevention, so activation reduces inflammation, relieves pain, and elevates mood.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027495/
Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB₂ Receptors and Blockade of the Related GPR55

Benzodiazepines, are some of the most commonly prescribed medications in the United States. These anxiolytics have many well-known side effects, including motor function, blurred vision, confusion, constipation, dizziness, drowsiness, memory problems, nausea, and many more.

In addition to abuse and dependence, other documented risks associated with benzodiazepine use include:

• Motor vehicle accidents. Driving while on benzodiazepines increases the risk of crashes to about the same as the risk of driving with a blood-alcohol level between 0.050% and 0.079% (1) (more than 0.08% is illegal in all states).
• Hip fracture. When taking benzodiazepines, the risk of hip fracture in older people increases by around 50%(1).

Distinctly different from benzodiazepines, DHH-B causes no effect on motor activity or muscle engagement and has been used to wean patients off benzodiazepines. As such, DHH-B may be a suitable option for people struggling with motor systems side effects of benzodiazepines.

(1) https://www.aafp.org/pubs/afp/issues/2013/0815/p224.html#afp20130815p224-b9

Like other magnolia bark extracts, DHH-B boosts GABA, a neurotransmitter that produces a calming effect. GABA soothes those neural properties that facilitate agitation, turmoil, and upheaval.

DHH-B (Dihydrohonokiol-B) is a natural derivative that has been researched for its benefits on mood and anxiolytic effects.

DHH-B for anxiety is ever popular. With an increased awareness of the unwanted side effects of benzodiazepines, DHH-B has been used by many to decrease daytime anxiety. This powerful natural anti-anxiety medicine also works well to facilitate sleep.

DHH-B supplement has also been researched for its ability to inhibit an overactive adrenal gland, lowering the hormone associated with stress and agitation

Honokiol is a poly-phenolic compound studied for its neuroprotective properties by a variety of mechanisms. Its therapeutic potential has been researched in anxiety, pain, cerebrovascular injury, epilepsy, and cognitive disorders. It has historically been used in Southeast Asia. Still, it has become more widely studied because of its pleiotropic (secondary and tertiary) effects.

Honokiol and its derivatives also act as a powerful antioxidant, lowering oxidative stress and in the brain and inflammation throughout the body.

Serotonin has been called the body's natural mood stabilizer. When serotonin levels are out of balance, people can suffer from low energy and “feeling blue.” 5-HTP can help. In fact, some studies have shown that 5-HTP supplementation can be just as effective in some people as traditional antidepressants.

Although more research is needed, early studies have shown that 5-HTP can help with depression by increasing serotonin levels. Multiple studies have reported that taking 150-3,000 mg of 5-HTP a day for 2-4 weeks may alleviate symptoms of depression.

5-HTP (5-Hydroxytryptophan) is a chemical by-product of the protein building block L-tryptophan. It is also produced commercially from the seeds of an African plant known as Griffonia simplicifolia 5-HTP is used for sleep disorders such as insomnia, depression, anxiety, migraine and tension-type headaches, fibromyalgia, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), seizure disorder, and Parkinson's disease..

5-HTP has the potential for use in the treatment of inflammatory diseases and oxidative stress. As a precursor of 5-HT, 5-HTP treatment is used to reduce depression, anxiety, and panic attacks. 5-HTP is associated with an increase in rapid eye movement (REM) sleep and reduces sleep disorder.

5-HTP supplements increase serotonin levels in your body, which could improve symptoms of depression, especially when used in combination with other antidepressant substances or medications. Nonetheless, more research is needed.

5-HTP is not recommended for people with Down syndrome, as it has been linked to seizures. Also, do not take 5-HTP less than two weeks before surgery as it may interfere with some drugs commonly used during surgical procedures. 5-HTP may interact with other medications as well.

A series of clinical studies suggest that BioPQQ supports cognitive health by promoting nerve growth factor in the brain as well as the creation of mitochondria, the powerhouse of cells that are critical to brain and heart functioning.

Interest in supplements to support brain health has risen dramatically in recent years. It’s not only older populations who are interested in maintaining brain health. Increasingly, younger consumers are seeking greater mental focus and acuity to keep up with today’s fast-paced lifestyle.

All-natural BioPQQ® is manufactured by Mitsubishi Gas Chemical 

Mitochondria are specialized structures inside your cells that are responsible for producing energy from the foods you eat.
PQQ supports proper mitochondrial function and the cellular development of new mitochondria.
PQQ’s exact function in humans remains somewhat undetermined, but it’s renowned for its potent antioxidant effects. It’s also thought to be involved in a variety of cellular processes, including protecting nerve cells against damage

May help lower inflammation

Early research indicates that PQQ has anti-inflammatory effects. In turn, these properties may reduce your risk of various inflammatory ailments.

One animal study found that mice given PQQ had significantly less inflammatory damage to brain tissue, compared with the control group (https://pubmed.ncbi.nlm.nih.gov/25314304/).

In another study in obese mice treated with PQQ during pregnancy and lactation, their offspring exhibited significantly fewer inflammatory markers in liver tissue and were less likely to express inflammatory genes than the offspring of mice that didn’t get PQQ (https://pubmed.ncbi.nlm.nih.gov/28007783/).

One small, 3-day study in 10 people evaluated the effects of taking a daily PQQ supplement on common markers of inflammation, such as C-reactive protein (CRP), interleukin-6 (IL-6), and blood sugar and cholesterol levels (https://pubmed.ncbi.nlm.nih.gov/24231099/).

CRP and IL-6 levels dropped significantly, but no meaningful changes in cholesterol or blood sugar occurred (https://pubmed.ncbi.nlm.nih.gov/24231099/).

May improve mitochondrial function

Recent research on PQQ largely focuses on its mitochondrial effects.

Mitochondria are responsible for producing the energy that your cells require to stay healthy and function optimally. Poor mitochondrial health is implicated in a variety of common conditions, including mental decline, heart disease, diabetes, and cancer (https://pubmed.ncbi.nlm.nih.gov/29163365/).

Experts note that enhanced mitochondrial health may be behind many of the broad health claims associated with PQQ, such as improved memory, energy, and sleep.

Several test-tube and animal studies indicate that PQQ increases cellular mitochondria production via several complex pathways, (https://pubmed.ncbi.nlm.nih.gov/29185343/, https://pubmed.ncbi.nlm.nih.gov/19861415/, https://pubmed.ncbi.nlm.nih.gov/26646764/).

Still, a small, 8-week study in 17 people found that taking 20 mg of PQQ daily resulted in significant self-reported improvements in sleep quality and fatigue (https://www.ffhdj.com/index.php/ffhd/article/view/81/175). The study authors noted that these effects may have been due to PQQ’s influence on mitochondrial health.

Nootropics are substances used to enhance brain functions like memory, mental focus, motivation, and creativity (https://pubmed.ncbi.nlm.nih.gov/27656235/).

PQQ supplements are manufactured via a unique bacterial fermentation process. The PQQ is harvested from certain bacteria that naturally produce this compound as a byproduct of their metabolism (https://www.sciencedirect.com/science/article/pii/B9780080885049002142).

Veterinarians commonly recommend glucosamine and chondroitin for treating osteoarthritis in canines despite the lack of compelling scientific evidence demonstrating clinical benefit.
Clinical trials to date have used different products, salt forms, doses, and dosing regimens such that comparing the results to draw meaningful conclusions about therapeutic efficacy is difficult (Addleman, 2010). In addition, pharmacists are often approached by pet owners with questions about the use of over-the-counter natural products in pets due to the availability of these products in pharmacies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356289/

It may take a few weeks to a few months for your dog to experience the full effects and gradual improvements associated with taking a glucosamine supplement

Even if you’re giving the right dosage in supplements to your dog, they may be getting additional glucosamine from other sources. For example, some brands of kibble contain glucosamine. While a little bit won’t make much of a difference, too much kibble will not only make them overweight but could lead to extra glucosamine in their body. Again, the chances of this being dangerous are extremely slim, but it’s important for optimal effectiveness that they receive the correct dosage.

Another possible way your dog could be getting extra glucosamine is from natural food sources. However, you would know if this was the case, as you would be feeding them raw foods such as chicken feet, oxtails, or shellfish shells. These raw foods are great sources of glucosamine that is very easily absorbed by your dog’s body, but it can be tough to provide these foods to your pup every day, which is why most pet parents choose supplements.

Glucosamine is more of a food supplement than a drug, so it's only in very rare cases when a dog consumes extreme amounts of glucosamine that a toxic overdose would occur. Most likely, your dog would experience some vomiting and/or diarrhea, with no lasting side effects.

Our NutraFitz Hip Bone & Joint Supplement does not contain any wheat or corn, or any ingredients which may cause an inflammatory response in the system. On the contrary, our joint supplement is packed with some of natures most powerful anti-inflammatory ingredients such as organic turmeric which combined with bioperine increases the absorption of the turmeric by up to 2000%. Our joint supplement also contains yucca which has been known to relieve and reduce symptoms and signs of arthritis. Our formula is designed to have your furry person regain the vitality of a two year old pup!

Our NutraFitz Hip Bone and Joint supplements are good for dogs starting at around 6 months old. If you have a certain breed or large pup, getting him started on glucosamine supplements early on could help prevent the onset of problems and help maintain his bone and joint health. You may want to ask your vet before you start your dog on any supplements.

For dogs 100lb's we recommend 3 tablets a day ( 1200mg) to be divided between AM & PM, meaning give 1.5 tablets in morning and 1.5 tablet in evening. Due to the all natural ingredients the tablet crumbles very easily and if your pup doesn't care for the taste, you can crumble it and mix with coconut oil ( which is very healthy for them) or with peanut butter or mix in the food. If you have any questions please contact us any time and we will be happy to assist you and provide additional support.

Glucosamine can be detected in a dog’s blood for up to 48 hours.
It should be administered daily, because it is rapidly absorbed, highly distributed, and efficiently excreted.

Some dogs may experience side effects from glucosamine, including the following:

• Gastrointestinal upset (especially when first starting glucosamine supplementation)
• Fatigue
• Bloated stomach

Glucosamine is a dietary supplement that may support joint health in dogs. Glucosamine is a safe supplement for pups—at high doses, it can cause increased thirst or an upset stomach. Doses for glucosamine are based the specifics of your dog. Talk to your vet for an appropriate dose.

Our joint supplement contains bone broth, made from ground bones with the bone marrow which is high in calcium, very good for bones.

It also contains powerful anti-inflammatory and antioxidants which could help as well.

Glucosamine regulates the synthesis of collagen in cartilage and may provide mild anti-inflammatory effects while chondroitin sulfate inhibits destructive enzymes in joint fluid and cartilage

Glucosamine and chondroitin use in canines for osteoarthritis: A review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356289/

Cat probiotics can help to keep your purry pet's troublesome gut symptoms under control, and veterinarians certainly recommend them as a way to boost your cat's overall health. However, it's essential to get your cat checked by a veterinarian if they are unwell before trying a probiotic at home.

Probiotics for dogs with itchy skin (including allergies and yeast infections) 
A probiotic for dogs may be beneficial to help prevent itching and scratching.
If your dog is licking at its paws, this can be not only extremely irritating for your dog but a sign of an underlying health condition.

• Constant Itching. Itching and scratching are frequent dog problems. ...
• Foul Odour. Yeast overgrowth is the most common cause of a stinky dog (Candida). ...
• Excessive Shedding. Excessive shedding is a symptom of physical stress. ...
• Dry and Flaky Skin. ...
• Ear Infection. ...
• Diarrhea.

There is 280 scoops of the pure "white stuff" per container. 

The POWER FLORA probiotics for dogs and cats is stable until it comes in contact with moisture ( water, digestive fluids, saliva, and raw moist food). Once you mix it with moist raw meats the moisture will bring the probiotic strains to life and it will not be as effective by the time you feed it to them ( If you were feeding dry kibble it wouldn't be an issue). Because of that it is recommended to mix it in right before feeding time.

The jar is big and the powder is very fine and the scoop is tiny and could get buried at the bottom of the jar. One scoop = 1/10 of a teaspoon which is difficult to come by, so you can use 1/8 tsp. There is no need to be concerned if you give a little more of the probiotics (you can't really overdose). 

For best results we suggest refrigeration after opening.